ABOUT

Vision to Action

Orger Lab

Our goal is to understand how the brain integrates sensory information and selects and executes appropriate actions. In particular, we aim to determine the organization and function of neural circuits underlying visually guided behaviors. We use the zebrafish as a model organism because it allows us to visualize and manipulate activity in neural circuits throughout a vertebrate brain. As early as one week post-fertilization, zebrafish display a rich repertoire of innate visual behaviors, following moving patterns, avoiding predators and tracking and capturing live prey. With no skull and transparent skin, the entire volume of the brain can be imaged non-invasively in one field of view, and many neurons are individually identifiable from fish to fish. Our approach has three main themes: 1) Quantitative analysis of behavior. 2) Whole brain imaging of neural activity dynamics in the behaving animal. 3) Perturbation of identified neurons to reveal their role in sensorimotor integration. In parallel, we are developing new genetic tools that allow more specific targeting and manipulation of identified cell types.

Info

Main Interests

Determine the principles on which sensorimotor circuits are organised and reveal how activity dynamics unfold throughout the whole brain during behaviour

Methods

High-speed behaviour tracking, Optogenetics, Whole-brain calcium imaging

Models and Regions

Zebrafish / Whole-brain

Opportunities

If you are interested in joining our group, please contact Michael Orger at the email address bellow.

michael.orger@neuro.fchampalimaud.org

Lab Webpage

orgerlab.org

PROJECTS

Vision to Action

TEAM

Vision to Action

Know our Team

Michael Orger

Michael Orger, PhD

Principal Investigator

Jens Bierfeld

Jens Bierfeld

2011 INDP PhD Student

Rita Félix

Rita Félix

2012 INDP PhD Student

Antonia Groneberg

Antonia Groneberg

2013 INDP PhD Student

Bernardo Esteves

Bernardo Esteves

Masters Student

Pedro Tomás

Pedro Tomás

Masters Student

Rita Esteves

Rita Esteves

Masters Student

Adrien Jouary

Adrien Jouary, PhD

Postdoctoral Fellow

Sabine Renninger

Sabine Renninger, PhD

Postdoctoral Fellow

Claudia Feierstein

Claudia Feierstein, PhD

Research Associate

Aaron Ostrovsky

Aaron Ostrovsky, PhD

Research Technician

Adinda Wens

Adinda Wens

Research Technician

Alexandre Laborde

Alexandre Laborde

Research Technician

António Martins

António Martins

Research Technician

Edite Figueiras

Edite Figueiras, PhD

Research Technician

Sofia Freitas

Sofia Freitas

Research Technician

Rita Saraiva

Rita Saraiva

Lab Administrator

PUBLICATIONS

Know our Publications