ABOUT

Immunophysiology

Veiga-Fernandes Lab

The interplay between diet, immune cells and intestinal microbes ensures vital functions of the organism, such as energy and micronutrient extraction from the diet, protection from pathogenic microbes and maintenance of a healthy epithelial barrier. These complex networks are of vital importance to organismic homeostasis, while inadequate relationships can lead to cancer and chronic inflammatory diseases, which are major Public Health concerns.
Adaptive immune lymphocytes express recombining antigen-specific receptors. These lymphocytes are activated by defined antigens and require a differentiation phase before exerting their effector function. In contrast, innate lymphocytes display rapid effector functions despite their set of limited germ-line encoded receptors. A mounting body of evidence indicates that in addition to their well-established developmentally regulated program, immune cells are also controlled by dietary signals and neuronal inputs. Thus, although there is tangible evidence suggesting that immune cells possess unexpected sensing strategies, how lymphoid cells perceive, integrate and respond to environmental cues remains poorly understood and vastly unexplored.
We centre our efforts on defining lymphocyte sensory mechanisms in health and disease. We use an integrative across-level approach aiming to elucidate the tenets of lymphocyte sensing and communication, within, across and beyond the organism.

Info

Main Interests

The role of cross-talk between neurons of the peripheral nervous system and the immune system in the prevention and resolution of disease

Methods

Genetic, molecular and cellular approaches, flow cytometry, confocal microscopy and in vivo models of disease

Models and Regions

Rodents / Mucosal barriers, such as the intestine and the lung

Opportunities

If you are interested in joining our group, please contact Henrique Veiga-Fernandes at the email address bellow.

henrique.veigafernandes@research.fchampalimaud.org

Lab Webpage

veigafernandeslab.org

PROJECTS

Immunophysiology

Know our Projects

Our long-term goal is to understand sensory and communication pathways that determine immune cell fate and disease progression. To achieve this, we centre our efforts at mucosal barriers that constitute the largest interface of the body with the external environment. Epithelial barriers line body surfaces and grant safeguard against harmful pathogens but are frequent targets of oncologic transformation and chronic inflammatory diseases. In this context, we tackle the following hitherto elusive points:

TEAM

Immunophysiology

Know our Team

Henrique Veiga-Fernandes

Henrique Veiga-Fernandes, PhD

Principal Investigator

Ana Filipa Cardoso

Ana Filipa Cardoso

External PhD Student

Rita Domingues

Rita Domingues

External PhD Student

Telmo Catarino

Telmo Catarino

External PhD Student

Sílvia Madeira

Sílvia Madeira

External Student

Hélder Ribeiro

Hélder Ribeiro

Lab Manager

Vânia Cardoso

Vânia Cardoso

PhD Student

Cristina Godinho da Silva

Cristina Godinho da Silva, PhD

Postdoctoral Fellow

Julie Chesné

Julie Chesné, PhD

Postdoctoral Fellow

Manuela Ferreira

Manuela Ferreira, PhD

Postdoctoral Fellow

Roeland Klein Wolterink

Roeland Klein Wolterink, MD, PhD

Postdoctoral Fellow

Roksana Pirzgalska

Roksana Pirzgalska, PhD

Postdoctoral Fellow

Bruno Raposo

Bruno Raposo

Research Technician

Miguel Rendas

Miguel Rendas

Research Technician

Sara Correia

Sara Correia

Technician

Telma Carrilho

Telma Carrilho

Lab Administrator

PUBLICATIONS

Know our Publications